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Breakthroughs in biomedical science have delivered life-saving therapies but at extreme costs, making these therapeutics frequently unaffordable to many patients. The decision-making processes for balancing medical needs with economic incentives and the complexity of the healthcare system are fraught with social, ethical, and political dimensions that most stakeholders are not equipped to address. This workshop will focus on these decision-making challenges and approaches to address them. It will also present advances in the new field of telemedicine and its role in improving the affordability of treatments and the efficiency of various components of healthcare systems.