Contemporary Challenges in Large-Scale Sequence Alignments and Phylogenies

Bridging Theory and Practice

August 11 — 14, 2025

Description

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With the increased availability of high quality sequence data and fully assembled genomes, the ability to construct large evolutionary trees is now mainly limited by the available mathematical models and computational methods. A key aspect of this workshop is the emphasis on scalable models and methods for phylogeny estimation, both of genes and of species, and for multiple sequence and multiple whole genome alignment, which are necessary precursors to these problems. This workshop will bring together mathematicians, probabilists, statisticians, computer scientists, and biologists at the forefront of these fascinating questions, with the goal of supporting the development of new theoretical advances and estimation methods that can scale to large datasets with high accuracy.

This workshop will include talks focused on theoretical contributions from mathematics and statistics, as well as talks focused on method development and analyses of biological datasets. A final day of the workshop (Thursday, August 14, 2025) will be devoted to a Software School, which will provide demos and tutorials of advanced software for topics discussed in the workshop; this Software School will be aimed at training biologists, from undergrads through postdocs, to use the current leading methods for multiple sequence alignment and phylogenetic estimation. A one-hour tutorial will be provided to introduce the concepts of the talks that will be presented, so that attendees who are relatively new to phylogenetics are able to understand the material.

Funding Requests

All funding requests must be submitted by June 17, 2025 to be considered.

Lightning Talks and Poster Session

This workshop will include lightning talks and a poster session for early career researchers (including graduate students). If accepted, you will be asked to do both. In order to propose a lightning session talk and a poster, you must first register for the workshop, and then submit a proposal using the form that will become available on this page after you register. The registration form should not be used to propose a lightning session talk or poster.

The deadline for proposing has been extended to June 17, 2025. If your proposal is accepted, you should plan to attend the event in-person.

Organizers

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S M
Siavash Mirarab University of California, San Diego
S R
Sébastien Roch University of Wisconsin, Madison
T W
Tandy Warnow University of Illinois, Urbana-Champaign

Speakers

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C A
Cécile Ané University of Wisconsin, Madison, Statistics and Botany
H B
Hector Baños California State University, San Bernardino
M H
Matthew Hahn Indiana University
L H
Lam Ho Dalhousie University
L N
Luay Nakhleh Rice University, Computer Science
B P
Benedict Paten University of California, Santa Cruz
T P
Tal Pupko Tel Aviv University, Molecular Cell Biology
C S L
Claudia Solis Lemus University of Wisconsin, Madison
Y S
Yun Song University of California, Berkeley (UC Berkeley)
Y T
Yatish Turakhia University of California, San Diego (UCSD)

Schedule

Monday, August 11, 2025
8:30-9:00 CDT
Welcome & Breakfast
9:00-9:20 CDT
Opening Remarks
9:20-10:00 CDT
Inferring mixtures of trees via multi-site weights

Speaker: Sébastien Roch (University of Wisconsin, Madison)

10:00-10:10 CDT
Q & A
10:10-10:15 CDT
Tech Break
10:15-10:55 CDT
Tree reconstruction from statistical perspectives

Speaker: Lam Ho (Dalhousie University)

10:55-11:05 CDT
Q & A
11:05-11:30 CDT
Coffee break
11:30-12:10 CDT
The good, the bad, and the ugly of deep learning in phylogenetics

Speaker: Claudia Solis-Lemus (University of Wisconsin, Madison)

12:10-12:20 CDT
Q & A
12:20-13:20 CDT
Lunch Break
13:20-14:00 CDT
Towards more realistic models of protein evolution

Speaker: Yun Song (University of California, Berkeley (UC Berkeley))

14:00-14:10 CDT
Q & A
14:10-14:15 CDT
Tech Break
14:15-15:15 CDT
Lightning Talks
15:15-16:30 CDT
Poster Session and Reception
Tuesday, August 12, 2025
8:30-9:00 CDT
Breakfast/Sign-in
9:00-9:40 CDT
Using Disjoint Tree Mergers for Large Tree Estimation

Speaker: Tandy Warnow (University of Illinois at Urbana-Champaign)

9:40-9:50 CDT
Q & A
9:50-9:55 CDT
Tech Break
9:55-10:35 CDT
GPU-Accelerated Construction of Ultra-Large Pangenomes via Alignment-Phylogeny Co-Estimation

Speaker: Yatish Turakhia (University of California, San Diego (UCSD))

10:35-10:45 CDT
Q & A
10:45-11:15 CDT
Coffee Break
11:15-11:55 CDT
The Impact of Model Misspecification on Tree and Network Inference from Quartets

Speaker: Hector Baňos (California State University, San Bernardino (CSU San Bernardino))

11:55-12:05 CDT
Q & A
12:05-13:05 CDT
Lunch Break
13:05-13:55 CDT
Open Problems Session
13:55-14:00 CDT
Tech Break
14:00-14:40 CDT
Using machine learning as an alternative to phylogenetic bootstrap and for quantifying MSAs

Speaker: Tal Pupko (Tel-Aviv University)

14:40-14:50 CDT
Q & A
14:50-15:30 CDT
Coffee break
15:30-16:10 CDT
A unified model of duplication, loss, introgression,and coalescence

Speaker: Matt Hahn (Indiana University)

16:10-16:20 CDT
Q & A
Wednesday, August 13, 2025
8:30-9:00 CDT
Breakfast/Sign-in
9:00-10:00 CDT
Biology Panel

Panelists: Ed Braun (University of Florida, Gainesville), Lacey Knowles (University of Michigan, and Joe Thornton (University of Chicago).

10:00-10:30 CDT
Coffee break
10:30-11:10 CDT
Advances and challenges in phylogenetic network inference

Speaker: Luay Nakhleh (Rice University)

11:10-11:20 CDT
Q & A
11:25-12:05 CDT
Furthering our understanding of human genetic variation: the human pangenome reference project second release

Speaker: Benedict Paten (University of California, Santa Cruz (UC Santa Cruz))

12:05-12:15 CDT
Q & A
12:15-13:15 CDT
Lunch Break
13:15-13:55 CDT
Identifying features of phylogenetic networks from various data types

Speaker: Cécile Ané (University of Wisconsin, Madison)

13:55-14:05 CDT
Q & A
14:05-14:35 CDT
Coffee break
14:35-15:15 CDT
Distance calculation and phylogenetic placement using k-mers

Speaker: Siavash Mirarab (University of California, San Diego (UCSD))

15:15-15:25 CDT
Q & A
15:25-16:00 CDT
Closing Remarks
Thursday, August 14, 2025
0:00-0:00 CDT
SOFTWARE SCHOOL
8:30-9:00 CDT
Breakfast/Sign-in
9:00-9:30 CDT
ASTRAL/ASTER

Speaker: Siavash Mirarabbaygi and Shayesteh Arasti (University of California, San Diego (UCSD))

9:30-10:00 CDT
Phylonet

Speaker: Nick Sapoval (Rice University)

10:00-10:30 CDT
Coffee break
10:30-11:00 CDT
PhyloNetworks and JuliaPhylo packages for estimating, using and manipulating phylogenetic networks

Speaker: Cécile Ané (University of Wisconsin, Madison)

11:00-11:30 CDT
SNaQ

Speaker: Claudia Solís-Lemus (University of Wisconsin, Madison)

11:30-12:00 CDT
MSCquartets

Speaker: Hector Baňos (California State University, San Bernardino)

12:00-12:15 CDT
Survey
12:15-13:00 CDT
Lunch Break
13:00-13:15 CDT
Krepp

Speaker: Ali O.B. Şapcı (University of California, San Diego (UCSD))

13:15-13:30 CDT
BSCAMPP

Speaker: Eleanor Wedell (University of Illinois Urbana-Champaign)

13:30-13:45 CDT
CASTLES-Pro

Speaker: Yasamin Tabatabaee (University of Illinois at Urbana-Champaign)

13:45-14:15 CDT
Multiple Sequence Alignment

Speaker: Tandy Warnow (University of Illinois at Urbana-Champaign)


Registration

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