There have been many recent innovations in healthcare development and delivery that have the potential to greatly improve patient care and outcomes. Examples include breakthroughs in life-saving therapies, electronic healthcare records, telemedicine, artificial intelligence and blockchain applications. This creates the need to build new business models and analyze emerging risk management problems to improve the affordability and accessibility of healthcare. It also highlights the need to study systemic risk issues in the healthcare ecosystem and public policy decision making that balances medical needs with economic and financial incentives. The aim of the workshop is to provide a platform to present these multifaceted problems and discuss the associated modeling and quantitative approaches.